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Charles Weems

Current Research Projects
Principal Investigator Project Title

Weems, Charles

Luteal And Endometrial Lh Receptor Function Modulated By Pge1, Pge2, Lh, Pgf2A, And Estrogen

Weems, Charles Reproductive Performance In Domestic Ruminants

weems

Phone: 808-956-8337
Fax: 808-956-4883
Office: AgSci 314 K
weems@hawaii.edu

Click here to view Dr. Weems' research portfolio

Educational Background

B.S. East Tennessee State University 1964
M.S. East Tennessee State University 1966
Ph.D. West Virginia University 1975

Research Interests

Dr. Weems' research interests are in the areas of pregnancy establishment, maintenance of pregnancy and hormonal regulation of placental function and fetal growth during the last third of pregnancy. These represent research areas where the greatest improvement in production efficiency can be achieved. Establishment and maintenance of pregnancy involves hormonal, paracrine and cytokine signals of embryonic, fetal or maternal origin to maintain function of the corpus luteum and placenta. In sheep and cattle, this involves at least regulation of steroid secretion (progesterone, estradiol-17ß), prostaglandins, and pregnancy specific protein B secretion and their interaction. These influence implantation, uterine capacity and embryo transfer, and are perturbed by environmental and microbial-induced loss of pregnancy. Dr. Weems' group has published 10 refereed journal articles in the last three years. In addition, Dr. Weems is Endocrinology Editor for the refereed journal Prostaglandins.

Languages

English
Japanese

Recent Publications

*Weems, Y. S., Uchima T., Lennon, E., Raney, A., Humphreys, V., Goto, K.
and Weems, C. W. 2008. Mechanisn Whereby Nitric Oxide (NO) is
Antiluteolytic Rather Than Being Luteolytic. Prostaglandins and Other
Lipid Mediators. 85:33-41. *

*Weems, Y. S., L. Kim, V. Humphreys, V. Tsuda, and C. W. Weems. 2007.
Effect of Luteinizing Hormone (LH), Pregnancy Specific Protein B (PSPB),
or Arachidonic Acid (AA) on Ovine Luteal Tissue of the Estrous Cycle and
Pregnancy or Placental Secretion of Prostaglandins E_2 (PGE_2 ) and F_2
? (PGF_2 ?), and Progesterone In Vitro. Prostaglandins and Other Lipid
Mediators. 84:163-173. *

*Y. S. Weems, L. Kim, V. Humphreys, C. Yin, and C. W. Weems. 2007. What
Regulates Steroidogenesis by the Ovine Placenta? Prostaglandins and
Other Lipid Mediators. 84:54-65.*

*Weems, C. W., Y. S. Weems, and R. D. Randel. 2006. Prostaglandins and
Reproduction in Female Farm Animals. The Veterinary Journal.
171/172:206-228. *

*Y.S. Weems, R.D. Randel, S. Tatman, A. W. Lewis, D. A. Neuendorff and
C.W. Weems. 2005. /In vivo /Progestin Treatments Inhibit Nitric Oxide
and Endothelin-1-Induced Bovine Endometrial Prostaglandin (PG) E (PGE)
Secretion /In Vitro/. Prostaglandins and Other Lipid Mediators. 78:276-290.*

*Weems, Y. S., E. Lennon, T. Uchima, A. Raney, K. Goto, A. Ong, H.
Zaleski, and C. W. Weems. 2005. Is Nitric Oxide Luteolytic or
Antiluteolytic?. Prostaglandins and Other Lipid Mediators. 78:141-150.*

*Weems, Y. S., R. D. Randel, S. Tatman, A. Lewis, D. A. Neuendorff and
C. W. Weems. 2004. Effects of Estrous Synchronization on Response to
Nitric Oxide Donors and Endothelin-1 In Vitro. Prostaglandins and Other
Lipid Mediators. 74:45-59.*

*Weems, Y. S., R. D. Randel, G. Carstens, T. Welsh, Jr., and C. W.
Weems. 2004. Do Calcium-Mediated Cellular Signalling Pathways,
Prostaglandin E2_ (PGE2), Estrogen or Progesterone Receptor Antagonists,
or Bacterial Endotoxins Affect Bovine Placental Function? Prostaglandins
and Other Lipid Mediators. 73:265-278.*

*Weems, Y. S., L. Kim, V. Humphreys, V. Tsuda, and C. W. Weems. 2003.
Effect of Luteinizing Hormone (LH), Pregnancy Specific Protein B (PSPB),
or Arachidonic Acid (AA) on Ovine Endometrium of the Estrous Cycle or
Placental Secretion of Prostaglandins E_2 (PGE_2 ) and F_2 ? (PGF_2 ?),
and Progesterone In Vitro. Prostaglandins and Other Lipid Mediators
71:55-73.*

*Weems, Y. S., A.W. Lewis, R. D. Randel, and C. W. Weems. 2002. Effects
of Prostaglandins E_2 and F_2 ? (PGE_2 ; PGF_2 ?), Trilostane,
Mifepristone, Palmitic Acid(PA), Indomethacin(INDO),
Ethamoxytriphetol(MER-25), PGE_2 +PA, or PGF_2 ? on PGE_2 , PGF_2 ?, and
Progesterone by Bovine Corpora Lutea of Mid-pregnancy In Vitro. Chinese
Journal of Physiology. 45(4):163-168.*

*Weems,Y.S., P.J. Bridges, R.G. Sasser, B.R. LeaMaster, and C.W.
Weems.2002. Effects of Mifepristone on Pregnancy and Secretion of
Progesterone, Estradiol-17?, Pregnancy Specific Protein B (PSPB), and
Prostaglandins E and F2? (PGE;PGF2?) in 90-day Intact Pregnant Sheep.
Prostaglandins and Other Lipid Mediators. 70:195-208.*

*Weems, Y.S., P.J. Bridges, R.G. Sasser, B.R. LeaMaster, L. Ching and
C.W. Weems. 2001. Effect of an Aromatase Inhibitor, CGS-16949A, on
Secretion of Estradiol-17?, Pregnancy Specific Protein B (PSPB),
Progesterone, and Prostaglandins E and F2? (PGE;PGF2?) in 90-Day
Ovariectomized Pregnant Sheep. Prostaglandins and Other Lipid Mediators.
66:77-87.*

*Kim, L., Y.S. Weems, P.J. Bridges, B.R. LeaMaster, D.L. Vincent and
C.W. Weems. 2001. Effects of Indomethacin, Luteinizing Hormone (LH),
Prostaglandin E2 (PGE2), Trilostane, Mifepristone,
Ethamoxytriphetol(MER-25), or Pregnancy on Secretion of Prostaglandin
E(PGE), Prostaglandin F2?(PGF2?) and Progesterone By Ovine Corpora Lutea
of Pregnancy or the Estrous Cycle. Prostaglandins and Other Lipid
Mediators. 63:189-203.*