Assistant Prof.

Education

Ph. D. 1998, Peptide synthesis Proteomics, University of Queensland, Brisbane, Australia.

B. Sc. (Hons.), 1992, Clinical Chemistry Toxinology, Griffith University, Queensland, Australia

B. Sc. 1991, Biochemistry, Griffith University, Queensland, Australia

Experiences

Ass. Professor, 2007 to Present, Peptide Synthesis, University of Hawaii at Manoa

Ass.Res.Professor, 2006, Peptide Synthesis Toxinology, Clarkson University, Postdam, New York.

Post-doc, 2003, Peptide Synthesis Toxinology, Yale School of Medicine, New Haven, Conneticut

Post-doc, 2000, Protenomics, University of California, Sanfrancisco, California

Areas of Interest

Marine Peptide Biochemistry

My main interest is with the discovery of novel biologically active peptides from venomous creatures and furthering their biological application(s) via bioengineering.
These include:
• Novel approaches to peptide isolation, characterization (encompassing proteomic and nano-technologies)
• Assigning their pharmacological targeting/actions
• Methods for chemical synthesis: peptide production and selective disulfide bond formation
• Structural design and methods for bioengineering peptides for labeling applications (e.g. fluorescent labeling, radio-labeling, affinity matrix conjugation etc.)

Community and International Work

Recent Book Chapters and Magazine Articles

Bingham J., Jones, A., Alewood, P. F, and Lewis, R. J. (1996) Conus Venom Peptides (Conopeptides): Inter-Species, Intra-Species and Within Individual Variation Revealed by Ionspray Mass Spectrometry. In: Biochemical Aspects of Marine Pharmacology, pp13-27. Ed Lazarovici, P., Spira, M. E. and Zlotkin, E., Alaken Inc., Fort Collins, Colorado, USA.

Nelson L. (2004) Venomous snails: one slip, and you're dead...
Nature. 2004 Jun 24; 429(6994): 798-9.

Chang A. (2004) ‘Researcher Risks Killer Snails for Study: Farming Venomous, Killer Cone Snails for Research Is a Risky Affair for Biochemist’. Released by Associated Press.

ScienCentral, Inc. – Medical textbook: A Colour Atlas of Tropical Medicine and Parasitology –2005/06

Scientific America “A Toxin against Pain” – Gary Stix – 2005

Featured in ‘Keeping up with the Cones’ Natural History, February 2002, Vol. 11. No. 1 p40-47 - 2002

Recent Publications

Xiao Y, Bingham JP, Zhu, W, Moczydlowski E, Liang S, Cummins TR. (2008) Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration. (Papers In Press, published online ahead of print July 14, 20).

Bingham, J-P., Bian, S. Tan, Z-Y., Takacs Z. and Moczydlowski E. (2006) Synthesis of a Biotin Derivative of Iberiotoxin: Binding Interactions with Streptavidin and the BK Ca2+-activated K+ Channel Expressed in a Human Cell Line. Bioconjugate Chem.; 17(3):689 - 699.

Krishnan M. N., Bingham, J-P., Lee, S. H., Trombley, P. and Moczydlowski E. (2005) Functional Role and Affinity of Inorganic Cations in Stabilizing the Tetrameric Structure of the KcsA K+ Channel. J Gen Physiol.;126(3):271-83.

Bingham J-P., Broxton N. M.,  Livett L.G,. Down, J. G., Jones A. and. Moczydlowski E.G. (2005) Optimizing the connectivity in disulfide-rich peptides: conotoxin SII as a case study. Anal. Biochem. 338(1):48-61.

Jakubowski, J.A., Keays, D.A., Kelley, W.P., Sandall, D.W., Bingham, J-P., Livett, B.G., Gayler, K.R. and Sweedler, J.V., (2004) Determining Sequences and Post-Translational Modifications of Novel Conotoxins inConus victoriae Using cDNA Sequencing and Mass Spectrometry. Rapid communications in Mass. Spect,.(in press).

Duda , T.F. Jr., Bingham, J.P., Livett, B.G. Kohn, A.J., Massilia, G. R., Schultz J.R., Down J., Sandall, D., Sweedler J.V. (2004) How much at risk are cone snails? Science. 2004 Feb 13;303(5660):955-7.

Bingham, J-P., Bian, S., and Moczydlowski E. (2003) Synthesis of iberiotoxin-D19K-LC-Biotin: application to BK channels. Biophys. J.  84: abstract.

Marshall, J., Kelley, W.P., Rubakhin, S. S., Bingham J-P., Sweedler  and Gilly W.F. (2002) Anatomical Correlates of Venom Production in Conus californicus.The Biological  Bulletin  203, p 27-41.

Sandall, D.W., Satkunanathan, N., Bingham, J-P., Moczydlowski, E., Down, J.G., Livett, B.G. and Gayler, K.R. (2002) Alpha-conotoxins from Conus anemone. Proc. 6th Asia-Pacific Congress on Animal, Plant and Microbial Toxins. Int. Soc. Toxinology, Symposium 19, Paper 2, Cairns, July 8-12, 2002, p. 85.

Bingham, J-P., Burlingame, A., Moczydlowski, E., Gilly, W.F. (2000) A new highly selective conotoxin from Conus californicus that targets voltage-gated neuronal Na+ channels of squid. Journal of General Physiology. 116:12a-13a.

Hill J. M., Oomen C. J., Miranda L. P., Bingham J-P., Alewood P. F., and Craik D. J. (1998) Three-Dimensional Solution Structure a of a-Conotoxin MII by NMR Spectroscopy: Effects of Solution Environment on Helicity. Biochem, 37, 15621.

Jones A., Bingham J-P., Gehrmann J., Bond T., Loughnan M., Atkins A., Lewis R. J., and Alewood P. F. (1996) Isolation and Characterization of Conopeptides by High-performance Liquid Chromatography Combined with Mass Spectrometry and Tandem Mass Spectrometry. Rapid communications in Mass. Spect,. 10, 138.

Lewis R. J., Bingham J., Jones A., Alewood P. F., and Andrews P. R. (1994) Drugs from the peptide venoms of marine Cone Shells. Australian Biotechnology. 4 298-300.

Invited lectures (local and international)