Education/Employment:  

• Assistant Professor – Dept. of Molecular Bioscience and Bioengineering, University of Hawaii, Honolulu, HI, 2007-present

• Assist Research Professor – Dept. of Biology, Clarkson University, Potsdam, NY 2003-2007

• Post-doctoral position – Dept. of Pharmacology, Yale School of Medicine, New Haven, CT 2000-2003

• Post-doctoral position – Mass Spectrometry Facility, Dept of Pharmaceutical Chemistry, University of California, San Francisco, CA, 1998-2000

• PhD. in Biochemistry  – Center for Drug Design and Development, Dept of Biochemistry, University of Queensland, Brisbane, Australia, 1993 – 1998

• B.Sc. (Hons.)  –  School of Science, Griffith University, Brisbane, Australia, 1992

• B.Sc.  –  School of Science, Griffith University, Brisbane, Australia, 1989 – 1991

 

Professional Membership:

• The American Peptide Society (2012– present)

• The American Chemical Society (2006 – present)

• Advancing Science, Serving Society (AAAS; 2004 – present)

• The International Society on Toxinology (2003 – present)

• The Malacological Society of Australasia (1992 – present)

• The Federation of Clinical Biochemists (1991– present)

Professional Awards/Recognition:

Excellence in Instruction College Teaching Award, University of Hawaii, Manoa - 2011

 

Scientific Advisor/Editor:

• Review Editorial Board of Frontiers in Chemical Biology (Frontiers) 2013 – present

• Member of the Editorial Board – Journal of Toxins (Hindawi Publishing Corp) 2012 – present

• Vice President of and Program coordinator to the Hawaiian Malacological Society – 2012 – present

• President of and Scientific Advisor to the Hawaiian Malacological Society – 2011 – 2012

• Board Director and Scientific Advisor to the Hawaiian Malacological Society – 2009 – 2010

 

Peer-reviewed Scientific publications (Total 21): (UHM Student work;*undergraduate/graduate at time of publishing

2013

1. Espiritu M.J, Collier A.C, Bingham J-P. (2013) A 21st Century Approach to Age Old Problems: the ascension of biologics over the small molecule therapeutics. Drug Discovery Today – in press .

2. Kapono CA, Thapa P., Cabalteja CC, Guendisch D. Collier AC and Bingham J-P. (2013) Conopeptide truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus – Toxicon 70, 170–178.

3. Negi V.S., Bingham J-P., Li Q.X., Borthakur D. (2013) midD-encoded 'rhizomimosinase' from Rhizobium sp. strain TAL1145, catabolizes Lmimosine into 3-hydroxy-4-pyridone, Amino Acids. 2013 Jun;44(6):1537-47.

4. Devappa R.K., Bingham J-P. and Khanal S.K. (2013) New and modified high performance liquid chromatography method for rapid quantification of phorbol esters in Jatropha curcas seed. Industrial Crops and Products 49:211-219.

2012

5.Bergeron ZL, Bingham JP (2012) Scorpion Toxins Specific for Potassium (K+) channels: A Historical Overview of Peptide Bioengineering. Toxins 4, 1082-1119

6.Bingham JP, Andrews EA, Kiyabu SM*, Cabalteja CC (2012) Drugs from Slugs, Part II – Conopeptide Bioengineering. Chemico-Biological Interactions 200 (2012) 92–113.

7.Bingham JP, Baker MR, Chun JB. (2012) Analysis of a cone snail's killer cocktail - The milked venom of Conus geographus. Toxicon.  Nov;60(6):1166-70 –

8.Chun JB, Baker MR, Kim D H, Leroy M, Toribo P, Bingham JP (2012) Cone snail milked venom dynamics – a quantitative study of Conus purpurascens. Toxicon. 60(1):83-

2011

9. Gilly W.F., Richmond T.A., Duda, Jr. T.F., Elliger C., Lebaric, Schulz J., Bingham JP., Sweedler J.V. (2011) A Diverse Family of Novel Peptide Toxins from an Unusual Cone Snail, Conus californicus.  The Journal of Experimental Biology. 214:147-61.

2010

10. Bingham JP., Mitsunaga E., Bergeron Z.L. (2010) Drugs from Slugs – Past, Present and Future Perspectives of omega-Conotoxin Research. Chemico-Biological Interactions 183 pp. 1-18.

2009

11. Bingham JP, Chun JB, Ruzicka MR, Li QX, Tan ZY, Kaulin YA, Englebretsen DR, Moczydlowski EG. (2009) Synthesis of an iberiotoxin derivative by chemical ligation: a method for improved yields of cysteine-rich scorpion toxin peptides. Peptides. 30(6):1049-57.

12. Townsend, A.*, B. G. Livett, J.-P. Bingham, H.-T. Truong, J. A. Karas, P. O’Donnell, N. A. Williamson A. W. Purcell, D. Scanlon, Mass Spectral Identification of Vc1.1 and Differential Distribution of Conopeptides in the Venom Duct of Conus victoriae. Effect of Post-Translational Modifications and Disulfide Isomerisation on Bioactivity. Int. J. Pept. Res. Ther., (2009)15 (3): 195-203.

2008

13. Xiao Y, Bingham JP, Zhu, W, Moczydlowski E, Liang S, Cummins TR. (2008) Tarantula Huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration. J Biol Chem. 3;283(40):27300-13.

Published Book Chapter:

• Bingham J-P., R.K. Likeman, J.S. Hawley, P.Y.C. Yu*, and Z. A. Halford (2014) Conotoxins. In: Manual of Security Sensitive Microbes and Toxins, Ed. D. Liu; CRC Press ISBN: 1466553960 - in Press

Published Editorials:

1. Bingham J-P., (2010) It’s about being compliant – Insight into the new regulations that govern Federal training awards and grants CTAHR Research News. July-August. Vol, 6 Iss. 6 (50). 19-23.

2. Bingham J-P., Chun J.*, Kim D.H.* and Milisen J.* (2010) Local ‘killer’ slugs provide novel leads for medical science and pesticide development. CTAHR Research News. Jan. Vol, 6 Iss. 1 (45). 3-10.

Invited Speaker/ Key Note speaker:

• Slugs, Drugs and Pesticides – The Emergence of the Cyclotides, Vanderbilt Institute of Chemical Biology Seminar Program, March 23, 2011

• Bioactive Peptides from Cone snails: cannibalistic slugs that kill, 23rd American Peptide Symposium & 6th International Peptide Symposium, Hilton Waikoloa Village Big Island, Hawaii, June 22-2, 2013.

 

Sponsor and Host:

• Sathish Kumar (2014) Fulbright-Nehru Doctoral and Professional Research Fellowships (India); Project: Conus venoms and source of novel bioactivity.

• Zenaida Baoana (2012-2013) Fulbright-Philippine Agriculture Scholarship Program for Advanced Research Award; Project: Culture and Propagation of Cone Snails (Conus)

• Project P20 – Research Conference for Middle School Students, May 16, 2013, UMH, HonoluluDNA/Genetics Workshop 7 FIRST Pre-Academy Research Experience for Teachers (RET) March 3, 2012, UMH, Honolulu.

• DNA/Genetics Workshop 7 FIRST Pre-Academy Research Experience for Teachers (RET) March 3, 2012, UMH, Honolulu.

 

Publications and Posters in International and University of Hawaii Conference Proceedings (Shown 2011 – present):

2013

1. Z.L. Bergeron, D.W. Sandall, B.G. Livett and J.P. Bingham. Analysis of Milked Venom from the Mollusc-hunting Cone Snail, Conus textile. Abstract #: 86032; 23rd American Peptide Symposium & 6th International Peptide Symposium, June 22-27, 2013.

2. Z.L. Bergeron, A.C. Collier and J.P. Bingham. Peptide Toxin Bioengineering - Advancement of Fluorescent Probe Design for Targeting Human K+ Channels. Abstract # XXX, 23rd American Peptide Symposium & 6th International Peptide Symposium, June 22-27, 2013.

3. Parashar Thapa and J.P. Bingham. Optimization of Thiol-Ester ligation for expanding the potential of Native Chemical ligation. Abstract # 86605. 23rd American Peptide Symposium & 6th International Peptide Symposium, June 22-27, 2013.

4. Vishal S. Negi, Jon-Paul Bingham, Qing X. Li, and Dulal Borthakur. Biochemistry of Rhizobium and Leucaena leucocephala enzymes for degradation of mimosine.  Abstract # TBA. 22nd North American Symbiotic Nitrogen Fixation (NASNFC) Conference University of Minnesota, Minneapolis July 14-17, 2013.

5. Jannai T. Yafuso, Vishal Singh Negi, Jon-Paul Bingham, Dulal Borthakur. Characterization of O-acetylserine (thiol) lyase from Leucaena leucocephala. Abstract # 580.3 American Society for Molecular Biology and Biochemistry Annual Meeting, Experimental Biology, Boston Convention and Exposition Center in Boston, MA, April 20-24, 2013.  

6. Vincent Cleveland, J-P Bingham and Eunsung Kan. Simultaneous Adsorption and Heterogeneous Oxidation of Endocrine Disrupting Compounds in Wastewater Using Nano Metal Catalyst-Deposited Carbon Nanotubes. Abstract # 325879 AICHE (American Institute of Chemical Engineers) National Meeting, San Francisco, November 3-8, 2013.

7. Nancy Williams, Pineda, F., Lam, T.T., Bruce, C., Bergeron, Z.L., Bingham, J.P., Cantely, L., et al. Edman Sequencing and Amino Acid Analysis in the Modern Age. Abstract # C161 ASBMB 2013 Annual Meeting, Experimental Biology Boston Convention and Exposition Center in Boston, MA, April 20-24, 2013.  

8. Bergeron, Z.L. and Bingham, J.P. Bioengineering Peptide Toxins for the Development of Novel Molluscicides and the Protection of Food Crops from Tropical Pathogens in Hawaii. Achievement Rewards for College Scientists (ARCS) Foundation, Scientific Symposium - Poster Session, Honolulu, HI April 20, 2013.

9. Elizabeth Andrews*, Jeffrey Milisen, Jon-Paul Bingham. Effects of Diet Manipulation on Conotoxin Profiles in Fish-Eating Conus striatus. Abstract #1. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Poster).

10. Chino Cabalteja*, Parashar Thapa, Shaun Kiyabu, Joycelyn Chun, David Sandall, Bruce Livett and Jon-Paul Bingham. Expanding the α-Conotoxin Repertoire through Disulfide Bond Permutations. Abstract #6. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Poster).

11. Michael J. Espiritu* and Jon-Paul Bingham. Determination of the biochemical effects of naturally produced post translationally modified conotoxins in comparison to synthetic variants. Abstract #13. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Poster).

12. Zan Halford* and Jon-Paul Bingham. ‘On-glowing’ connections: Diversifying the approaches to fluorescent peptide bioengineering for investigating Potassium (K+) Channels Abstract #17. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Poster).

13. James Murphy*, Robert H. Richmond and Jon-Paul Bingham. Analyzing Changes to Coral Health and Metabolism in an Oxygen-Poor Environment. Abstract #29. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Poster).

14. David Slater* and Jon-Paul Bingham. Evaluating the Risk of Diphacinone Rodenticide Pellets to HawaiiaTrigger Fish. Abstract #36. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Poster).

15. Christopher Sugai*, Michael Espiritu, and J.P. Bingham. Characterization of Milked Venom from Conus obscurus in Search for Novel Bioactive Compounds. Abstract #39. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Poster).

16. Kristen Wheeler*, Ty McDonald, John Griffis, Theodore J. K. Radovich, and Jon-Paul Bingham. Method development and high performance liquid chromatographic analysis of flavonols and anthocyanins from Purple-fruited Selections of Eugenia uniflora L. (Pitanga).Abstract #42. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Poster).

17. Parashar Thapa*, Zeb Phillips, Chino Cabalteja and Jon-Paul Bingham. Optimization of novel Thiol-Ester ligation technique for expanding the potential of Native Chemical Ligation. Abstract #62. 25th CTAHR and COE search Symposium, University of Hawaii, Honolulu, April 12-13. (PhD. Student; Poster) - Gamma Sigma Delta PhD Student Poster Presentation.

18. Peter Yu* and Jon-Paul Bingham. Cone Snails, Cyclized Peptides, and Fluorophores – A Gateway to Traceable Peptides. Abstract #96. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (UG. Student; Poster) - MBBE Best Undergraduate Poster Presentation.

19. Shaun Kiyabu* and Jon-Paul Bingham. Conotoxin Cyclization Linker Molecules Through the Use of Molecular Modeling applicationsAbstract #104. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (UG. Student; Oral).

20. Vincent Cleveland*, Jon-Paul Bingham, and Eunsung Kan. Adsorption and Heterogeneous Oxidation of Endocrine Disrupting Compounds in Wastewater Using Nano Metal Catalyst-Deposited Carbon Nanotubes. Abstract #113. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (MS. Student; Oral) - CTAHR Best MS Student Oral Presentation.

21. Z.L. Bergeron*, A.C. Collier, J-P. Bingham. Validation of a Novel, Direct Conjugate Scorpion Toxin-Fluorophore for the Investigation of the Large Conductance Ca2+-activated Potassium Channel, BK. Abstract #132. 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13. (PhD. Student; Oral) - CTAHR Best PhD Student Oral Presentation.

2012

22. Bergeron, Z.L., Collier, A.C., Bingham, J.P. Peptide Toxin Bioengineering - Advancement of Fluorescent Probe Design for Targeting Human K+ Channels. John A Burns School of Medicine Spring Research Symposium (Honolulu, HI) (2012).

23. Liz Andrews, Jeff Milisen, and Jon-Paul Bingham (2012) “Effects of Diet Manipulation on Conotoxin Profiles in Fish-Eating Conus striatus”. Abstract #24. 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (MS. Student; Poster).

24. Chino Cabalteja, Shaun Kiyabu#, Joycelyn Chun, David Sandall, Bruce Livett and Jon-Paul Bingham (2012) “Challenging the Dogma that Bioactive α-Conotoxins are Globular”. Abstract #28. 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (MS. Student; Poster).

25. Zan Halford and Jon-Paul Bingham (2012) “Making connections with azido-chemistry: A novel approach to bioengineering peptide toxin fluorophores. Abstract #33. 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (MS. Student; Poster).

26. Jeff Milisen and Jon-Paul Bingham (2012) “Maximizing Conopeptide Production through Improved Snail Farming”. Abstract #42 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (MS. Student; Poster).

27. Parashar Thapa and Jon-Paul Bingham (2012) “Optimization of Thiol-Ester ligation for expanding the potential of Native Chemical ligation”. Abstract #53 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (MS. Student; Poster).

28. Shaun Kiyabu# and Jon-Paul Bingham. (2012) “Toxin folding patterns within the venom duct of the genus Conus”. Abstract #69 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (UG. Student; Poster).

29. Peter Yu#, Parashar Thapa, and Jon-Paul Bingham (2012) “Using an Optimized Methodology of TFMSA Cleavage in Peptide Synthesis Bioengineering”. Abstract #93 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (UG. Student; Poster).

30. David Slater# and Jon-Paul Bingham (2012) “Evaluating the Risk of Diphacinone Rodenticide Pellets to Hawaiian Trigger Fish”. Abstract #95 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (UG. Student; oral).

31. Jannai Yafuso, Vishal Singh Negi, Jon-Paul Bingham, and Dulal Borthakur. (2012) “Isolation and characterization of cDNAs encoding enzymes for mimosine biosynthesis in Leucaena leucocephala”. Abstract #100 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (MS. Student; oral).

32. Elizabeth Mahi, Alec Nordschow#, Jeff Milisen and Jon-Paul Bingham. (2012) “Cultivation of Planktotrophic Conus striatus Larvae”. Abstract #102 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (MS. Student; Oral).

33. Zachary L. Bergeron, Abby Collier and Jon-Paul Bingham. (2012) Peptide Toxin Bioengineering - Advancement of Fluorescent Probe Design for Targeting Human K+ Channels. Abstract #118 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (PhD. Student; oral).

34. Vishal Singh Negi, Jon-Paul Bingham, Qing X. Li, and Dulal Borthakur (2012) Characterization of mimosine-degrading enzymes from Rhizobium sp. strain TAL1145 and Leucaena leucocephala. Abstract #121 24rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 13-14. (PhD. Student; Oral).

2011

35. Kristen Wheeler, Ty McDonald, John Griffis, Theodore J. K. Radovich, Jon-Paul Bingham and Malcolm M. Manners. (2011) Flavonol and Anthocyanin Analyses of Purple-fruited Selections of Eugenia uniflora L. (Pitanga) by High Performance Liquid Chromatography. American Society for Horticulture Science. Waikola, HI. Sept. 25-28th

36. Cabalteja C., Kiyabu S. #, Chun J., Sandall D., Livett B., and Bingham J-P (2011) Challenging the Dogma that Bioactive α-Conotoxins are Globular "Big Research, Little Island" Summer Showcase 2011 McNair Student Achievement Program, University of Hawaii, Honolulu, August 8-9.

37. Kiyabu S. #, Cabalteja C., Chun J., Sandall D., Livett B., and Bingham J-P (2011) Selective Disulfide Bond Formation in conotoxins INBRE SURI program, University of Hawaii, Honolulu, July 29th.

38. Chun J.B.S., Kim D.H. and Bingham J-P. (2011) "Exploring different approaches to identify novel drug lead candidates within Conus purpurascens". Abstract #32. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (MS. Student).

39. Halford Z., and Bingham J-P. (2011) "Exploring Azido-chemistry: A Novel approach to peptide toxin bioengineering and fluorophore production". Abstract #34 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (MS. Student).

40. Mahi E., Nordschow A. #, Milisen J. and Bingham J-P. (2011) "Cultivation of planktotrophic Conus textile larvae". Abstract #48. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (MS. Student).

41. Milisen J., Mahi E., Leong J. # and Bingham J-P. (2011) "Venom variability in Conus striatus" Abstract #50. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (MS. Student).

42. Nordschow A. #, Milisen J. and Bingham J-P. (2011) "Developmental analysis through protein quantification of Conus striatus veliger" Abstract #53. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (Undergraduate).

43. Spafford D., Cuttriss A., Christopher D., Smith C., and Bingham J-P. (2011) "Identification of photoprotective pigments in Gracilaria salicornia, an invasive red macroalga". Abstract #58. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (MS. Student).

44. Thapa P. and Bingham J-P. (2011) "Optimization of Thiol-ester mediated ligation for peptide synthesis and bioengineering" Abstract #60. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (MS. Student).

45. Wheeler K., McDonald T., Griffis J., Radovich T.J.K., Bingham J-P. and. Manners. M.M (2011) "Flavonol and Anthocyanin Analyses of Purple-fruited Selections of Eugenia uniflora L. (Pitanga) by High Performance Liquid Chromatography". Abstract #63. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (MS. Student).

46. Maldonado A. #, Milisen J. and Bingham J-P. (2011) "Demonstration of molluscicidal activity targeting pomacea canaliculta (Golden Apple Snail)". Abstract #90. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (Undergraduate)

47. Spann N. # and Bingham J-P. (2011) "Non-Translationally Modified Toxins as Molluscicides" Abstract #96. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (Undergraduate).

48. Kapono C., Thapa P., Guendisch D. and Bingham J-P. (2011) "α-Conotoxin truncation – an investigation into the pharmacological and phyla specificity of venom peptides". Abstract #69. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (MS. Student) (oral).

49. Bergeron Z.L., Milisen J., Chun J. and Bingham J-P. (2011) "Venom From A Far; How a Cone Shell Will Travel". Abstract #124. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (PhD. Student) (oral).

50. Yafuso E., Bingham J-P., Chen J., Turano H., Teresita Amore T. and Paull R.E. (2011) "Functional characterization of a Dendrobium F5’3’H gene in the Petunia model system". Abstract #130. 23rd CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 8-9. (PhD. Student) (oral).

Undergraduate Student Awards (10):

2013
Peter Yu – MBBE Best Undergraduate Poster Presentation - 25th CTAHR and COE Research Symposium. Project: Cone Snails, Cyclized Peptides, and Fluorophores – A Gateway to Traceable Peptides. Role: PI.
2012
Peter Yu – Gamma Sigma Delta Award of Merit (2nd place overall) at the 24th CTAHR and COE Student Research Symposium. Project: Using an Optimized Methodology of TFMSA Cleavage in Peptide Synthesis Bioengineering. Role: PI.
2011
Elizabeth Mahi – Student Research Award; Graduate Professional Access (GPA) Program. Project: Cultivation of planktotrophic Conus textile larvae. Role: PI.

Alec Nordschow – Best Research Presentation Poster Category Award. 28th Marine Option Program Student (MOPS) Symposium, University of Hawaii Hilo campus. Project: Developmental Analysis through Protein Quantification of Conus striatus Veliger. Role: PI.

Kenny Masuda – Research Award, University of Hawaii, Manoa, Undergraduate Research Opportunities Council. Project: Molecular finger-printing of Conus pennaceus from the Hawaiians Islands Role: PI.

Nolan Spann – MBBE Best Undergraduate Poster Presentation 23rd CTAHR Student Research Symposium. Project: Non-Translationally Modified Toxins as Molluscicides Role: PI.

Shaun Kiyabu – INBRE Summer Undergraduate Research Internship program. Project: Selective Disulfide Bond Formation in a-conotoxins Role: PI.
2010
Alec Nordschow – Best Research Project Category Award (oral). 27th Annual Marine Option Program Student (MOPS) Symposium, University of Hawaii Hilo campus. Project: Developmental Analysis Through Protein Quantification of Conus striatus eggs. Role: PI.
2009
Parashar Thapa – Gamma Sigma Delta, Award of Merit, awarded in the category of Undergraduate Student Poster Presentation. 21st CTAHR Student Research Symposium, University of Hawaii Manoa campus. Project: Alpha conotoxin peptide truncation – a potential novel means of post-translational modification for phyla and pharmacological specificity. Role: PI.
2008
Jacob Ishibashi – PRIDE Summer Undergraduate Research Internship program. Project: Peptide probes: Addressing Problems in design and synthesis. Role: PI.

 

Graduate Student Awards (25):

2013
Zachary Bergeron – (a) Student Travel Fellowship for 23rd American Peptide Society Symposium/6th International Peptides Symposium. Hilton Waikoloa Village Big Island, Hawaii, June 22-27; (b) Achievement Rewards for College Scientists (ARCS) Foundation: Scholar of the Year (joint); (c) Achievement Rewards for College Scientists (ARCS) Foundation: Helen Jones Farrar award in Tropical Agriculture Research; (d) 25th CTAHR and COE Student Research Symposium – CTAHR Best PhD. Student Oral Presentation, Project: Validation of a Novel, Direct Conjugate Scorpion Toxin-Fluorophore for the Investigation of the Large Conductance Ca2+-activated Potassium Channel, BK. Role: PI.

Parashar Thapa – (a) Student Travel Fellowship for 23rd American Peptide Society Symposium/6th International Peptides Symposium. Hilton Waikoloa Village Big Island, Hawaii, June 22-27, 2013; (b) 25th CTAHR and COE Student Research Symposium – Gamma Sigma Delta PhD Student Poster Presentation, Project: Optimization of novel Thiol-Ester ligation technique for expanding the potential of Native Chemical Ligation, Role: PI.

Vincent Cleveland - 25th CTAHR and COE Student Research Symposium – CTAHR Best MS Student Oral Presentation, Project: Adsorption and Heterogeneous Oxidation of Endocrine Disrupting Compounds in Wastewater Using Nano Metal Catalyst-Deposited Carbon Nanotubes, Role: Co-PI.
2012
Chino Cabalteja – 24th CTAHR and COE Student Research Symposium. CTAHR Best MS Student Poster Presentation, Project: Challenging the Dogma that Bioactive α-Conotoxins are Globular, Role: PI.

Elizabeth Mahi – 24th CTAHR and COE Student Research Symposium. MBBE Best MS Student Oral Presentation, Project: Cultivation of Planktotrophic Conus striatus Larvae. Role: PI.

Zachary Bergeron – 24th CTAHR and COE Student Research Symposium. CTAHR PhD Student Oral Presentation Award of Merit, Project: Peptide Toxin Bioengineering - Advancement of Fluorescent Probe Design for Targeting Human K+ Channels, Role: PI.

Elizabeth Andrews – Representative for the American Society of Biochemistry and Molecular Biosciences Hill Day, Washington DC, Sept. 10-12, Role: PI.
2011
Cliff Kapono – (a) CTAHR Departmental Merit Scholarship Fall 2010; (b) Manoa Opportunity Grant Fall 2010/Spring 2011; 
(c) UHM second Century Scholarship Fall 2010/Spring 2011; (d) Kahuewai Ola Native Hawaiian Scholarship Fall 2010/Spring 2011; 
(e) Imi Na’auao Post Secondary Scholarship Fall 2010/Spring 2011; (f) Native Hawaiian Science and Engineering Mentorship program Malolo Award Fall 2010; (g) Kahuewai Ola Native Hawaiian Scholarship Fall 2011; (h) Tuition
Imi Naauao scholarship 2011l; 
(i) NSEMP scholarship 2011. Role: PI.

Erin Yafuso – The Board of Directors of the Pacific Orchid Society Award. 23rd Annual CTAHR Student Research Symposium. Project: Functional characterization of a Dendrobium F5’3’H gene in the Petunia model system. Role: Co-PI.

Zachary Bergeron – Gamma Sigma Delta, Award of Merit, awarded in the category of MBBE Best PhD. Student Oral Presentation 23rd Annual CTAHR Student Research Symposium. Project: Venom From A Far; How a Cone Shell Will Travel. Role: PI.

Kristen Wheeler – Student travel grant from the American Society for Horticulture Science. Sept. 25-28th Waikola, HI. Project: Flavonol and Anthocyanin Analyses of Purple-fruited Selections of Eugenia uniflora L. (Pitanga) by High Performance Liquid Chromatography. Role: PI.

Chino Cabalteja – McNair Summer Research Internship program. Project: Challenging the Dogma that Bioactive α-Conotoxins are Globular Role: PI.
2010
Do Kim – (2010) Gamma Sigma Delta, Award of Merit, awarded in the category of MBBE Best MS Student Oral Presentation. 22nd Annual CTAHR Student Research Symposium. Project: Bioengineering of ω-conotoxin GVIA: Probes for the N-type neuronal Ca2+ channel. Role: PI.

Zachary Bergeron – (2010) Federation of American Societies for Experimental Biology, Graduate Student Travel Scholarship; in Anaheim, CA, April 24-28. Project: Design development and application of a fluorescent probe to study changes in hERG channel density and trafficking; a mechanistic basis for cardiac arrhythmia. Role: PI.

Public Education:
(i) Special News Features (3):

1. National Geographic (2010/2011/2012/2013) “Venoms” (Producer: C. Cohen) – seen in 71 countries, viewed approximately by +17 million people world-wide.

2. Nelson L. (2004) Venomous snails: one slip, and you're dead... Nature. 2004 Jun 24; 429(6994): 798 – 9. Interview focused on cone shell milking and snail husbandry.

3. Chang A. (2004) Researcher Risks Killer Snails for Study: Farming Venomous, Killer Cone Snails for Research Is a Risky Affair for Biochemist. Released by Associated Press. - Article focused on cone shell work.

(ii) Scientific Advisor: in documentaries (10), Media production (8), textbook contributions (5), Public Education (25),

2007-Present: KHON2 Local News (2013) (Producer: Ron Mizutani), Hawaii Public Radio (2013) (Producer: Molly Solomon); OC16 Tech Hawaii (2011)  (Producer: Jay Fidel); Oelo 52 (2011) (Producer: Jay Fidel); Graber (2008) On the Tail of the Snail: Arts and Science for Kids (ASK) p 12-19; Kleinpaste R. (2008) Bug of the Month; Snorkeling at Night: New Zealand Growing Today, April p. 46.; Roberson M-R. (2008) Creature Comforts – Animals provide healing help for Humans, Zoogoer, Vol. 37 No.6 p18-23.; 60 Minutes “The bugman” – (2008)  (Aust.) (Producer: Damien Comerford) – CD available; EcoGeeks  - (2008) (Producer/interviewer Rob. Nelson; Wild Class Room) – CD available; Pearson Publishing BioAdventures (2008).

2006 – 2000: Videos on toxins and Cone Shells that will compliment every chapter of their new Miller and Levine High School Biology textbook (print 7 million copies a year for 9th graders); Animal Planet (2006): Buggin’ With Ruud (New Zealand Natural History); Flipside (UK; 2006): ‘Killer Sea Snails’ – Louise Murray; Radio 4, BBC Scotland (2005): 'Danger! Venomous snails’ – Louise Yeoman – CD available; Discovery Channel (2005; Canada): Daily Planet – Exploration Productions Inc.; Associate Press (2005): ‘Farming killer cone snails for research is a risky affair’ – A. Chang; National Public Radio (2005; USA): ‘Pulse of the Planet’: ‘Cone Shells  – Poison Tongued; Cone Shells – Fascination; Cone Shells  – medical uses’; ScienCentral, Inc.: Medical textbook: A Colour Atlas of Tropical Medicine and Parasitology; ODYSSEY, Cobblestone Publishing – Children’s Science Magazine: ‘Possibility is everywhere…even in  poisonous snails’ – Steven R. Wills.

(iii) Textbook advisor/reviewer for:

• Essentials of Biochemistry 3/e, by Pratt & Cornely (Wiley) (2012);

• Biochemistry by Mathews 5/e, by van Holde, & Ahern; Pearson (2012);

• Lehninger Principles of Biochemistry 6/e, by Nelson & Cox W. H.; WH Freeman Publisher’s (2012).

(iv) Invited Talks shown 2007 - present:

• Hawaiian Malacological Society (2008 – 2013/yearly);

• Waikki Aquarium – Meet the Mollusks (2011);

• Vanderbilt Univeristy, Nashville, Tenassee (2011);

• ACS (Hawaii)/ Forum in Chemistry at Windward Committee College (2010);

• Duquesne University, Pittsburg Pennsylvania (2010);

• ACS (Hawaii) – Annual Dinner (2009);

• University of Hawaii, Biology Club Manoa, Honolulu (2009);

• University of Hawaii, Chemistry Dept., Manoa, Honolulu (2009);

• Melbourne University, Melbourne Australia (2008);

• Clarkson University, Potsdam New York (2006 and 2007);

• University of Pennsylvania, Philadelphia (2007)

Referee/peer reviewer for a manuscript submitted to:
Analytical Biochemistry; Proteome; Peptides; Toxicon; Journal of Biological Chemistry - Drugs of the Future; Toxins; Journal of Biological Chemistry; Biochemistry; FEBS; Drug Discovery Today.

University, College and Departmental Service:

• Vice-President of the CTAHR Faculty Senate, 2013 – present

• Member of the CTAHR Faculty Senate Executive, 2011– present, Instructional Review Committee

• Represented CTAHR at Rat Lung Worm Disease Scientific Workshop, Honolulu, Aug. 16-18 (2011)

• Represented MBBE in May Commencement Exercises, 2008, 2009, 2010, 201, 2012 and 2013

• Represented MBBE in December Commencement Exercises, 2011

• Participant in the UH-Manoa Strategic Planning Process Focus Group session (October 2010)

• Represented CTAHR at Teaching “SURVIVAL SKILLS” AND ETHICS 16th Annual Trainer-of-Trainers Conference Supported by NIH, June 21-26, 2010, Santa Fe, New Mexico

• Member of the CTAHR Faculty Senate, 2009 – 2010, Instructional Review Committee

• Represented CTAHR on Faculty Panel—Striking a Balance: Teaching, Research, Service-for the New Faculty Orientation (Jan. 2009)

• Member of MBBE Graduate Steering Committee (2009)

• Represented MBBE on Biology Steering Committee (2008-2009)

• MBBE representative/shop steward for the University of Hawaii’s Professional Assembly, 2007-2009

• Scientific Judging Annual CTAHR Student Research Symposium:

• 2013 – Head judge CTAHR for 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13.

• 2012 – PhD. Posters; MS Orals, 24th CTAHR and COE Student Research Symposium.

• 2011 – MS orals (Chair); PhD. Posters (Chair), 23rd Annual CTAHR Student Research Symposium, April 8-9, Honolulu;

• 2010 – PhD orals (Chair); PhD. Posters (Chair);, 22nd Annual CTAHR Student Research Symposium, April 9-10, Honolulu;

• 2009 – PhD orals; PhD. Posters, 21st Annual CTAHR Student Research Symposium, April 3-5, Honolulu;

• 2008 – PhD orals; PhD. Posters, 20th Annual CTAHR Student Research Symposium, April 11-12, Honolulu;

• 2007 – PhD orals; PhD. Posters, 19th Annual CTAHR Student Research Symposium, March 9-10, Honolulu.

Graduate Student Thesis Committees, University of Hawaii:
 PhD Level (13; 6 current):
Past:
1. Devin Takara (PI Dr. Khanal) – graduated, 2013; Title: Green Processing of a Tropical Grass for Biofuel and Biobased Products.

2. Vishal Negi, MBBE (PI Dr. D. Borthakur) - graduated 2012; Title: Biochemistry of mimosine catabolism by enzymes from Rhizobium sp. TAL1145 and Leucaena leucocephala.

3. Alejandro Preciado, Dept. of Chem. (PI Dr. P. Williams) – graduated, 2012; Title: Stereochemistry of -Amino--Hydroxy Acids of Natural and Synthetic Origins.

4. Maribel Zaporteza, MBBE (PI Dr. W. Su) – graduated, 2011; Title

5. Eun Ju Cho, MBBE (PI Dr. D. Christopher) – graduated, 2011; Title: Identification, Characterization, and sub-cellular localization 
of Protein Disulfide Isomerase (PDI) in Arabidopsis thaliana.

6. Sreeramula Kalluri, Chemistry (PI Dr. J. Garret); Title: Biosynthesis of Thuricin CD – terminated, 2013

7. Norman Wang, MBBE (PI Dr. G. Presting) – terminated, 2012

Current:
1. Zachery Bergeron, MBBE (Chair); Title: Peptide Toxin Bioengineering Advancement of Fluorescent Probe Design for Targeting Human K+ Channels. ABD.

2. Archanal Pal, MBBE (PI Dr. D. Borthakur); Functional Characterization of Chloroplastic and Cytoplasmic -Carbonic Anhydrase Isoforms from Leucaena leucocephala. ABD.

3. Parashara Thapa, MBBE (Chair); Title: Bioengineering of conopeptides to study the pharmacokinetics and pharmacodynamics of peptide cyclization.

4. Nhan Hua, MBBE (PI Dr. H. Ako); Title: Development of Aquaculture Technology for the Hawaiian Opihi Cellana spp.

5. Margaret Baker, MBBE (PI Dr. X. Li); Ttile: Structure characterization of windmill palm peroxidase in relation to roles of glycosylation on stability and catalysis.

6. David Spafford, Botany (PI Dr. Celia Smith); Title TBD

 MSc Level (23; 11 current):
Past – Plan A:
1. Kristen Wheeler, MBBE (Chair) – graduated 2013; Title: Quantitative Chemical Analysis of Flavonoids in Purple Fruited Selections of Pitanga (Eugenia uniflora L.).

2. Jeffery Milisen, MBBE (Chair) – graduated 2012; Title: Conopeptide Production through Biosustainable Snail Farming.

3. Cliff Kapono, MBBE (Chair) – graduated 2012; Title: Characterization of Novel Conotoxins Derived from the Milked Venom of Conus magus.

4. Majdouline LeRoy, MBBE (PI Dr. S. Khanal) – graduated 2012; Title: Ultrastructural Changes Associated with Different Pretreatments on Napier Grass.

5. Isabel Rushanaedy, MBBE (PI Dr. D. Borthakur) – graduated 2012; Title: Chitinase as Molecular
Bioindicator of Resistance to Fusarium oxysporum in Acacia koa.

6. Joycelyn Chun, MBBE (Chair) – graduated 2011; Title: Exploration of Novel Techniques and Approaches in the Study of Conopeptides.

7. Zeb Philips, MBBE (Chair) – graduated 2010; Title: Thiol-mediated Ligation and Characterization of Native and Mutant Huwentoxin-I Peptides on Voltage-gated Sodium Channels (Nav).

Past – Plan B:
1. Elizabeth Mahi, MBBE, graduated 2012; Report: Cultivation of planktotrophic Conus striatus larvae.

Current – Plan A:
1. Zan Halford, MBBE (Chair); Title: Peptide bioengineering of a kv1.3 channel probe: utilizing azide chemistry in fluorescent bioconjugation.

2. Liz Andrews, MBBE (Chair); Title: Effects of Diet Manipulation on Conopeptide Profiles in Fish-Eating Conus striatus.

3. Chino Cabalteja, MBBE (Chair); Title: The means and ends all to thiol chemistry - a peptide journey from disulfide bonds to thiol-ester ligation

4. Christopher Sugai, MBBE (Chair); Title: Characterization of Milked Venom from Conus obscurus in Search of Novel Bioactive Compounds.

5. Michael Espiritu, MBBE (Chair); Title: Exploring the Post Translational Modifications of Conus Peptides and their influence on isomer formation and biological activity.

6. Simon Che MBBE (PI Dr. A. Collier); Title: Post-Translational Protein Glycosylation as a Mechanism for Neonatal Maturation of UDP-Glucuronosyl Transferase Enzymes.

7. Steffen Oeser MBBE (PI Dr. A. Collier); Title: The effects of obesity on UDP-glucuronosyl transferase enzymes expression and activity.

8. Jannai Yafuso, MBBE (PI Dr. D. Borthakur); Title: Isolation and characterization of O-acetylserine(thiol) lyase from Leucaena leucocephala.

9. David Slater MBBE (Chair); TBA

10. Peter Yu MBBE (Chair); TBA

11. Shaun Kiyabu (Chair): TBA

12. Do Kim MBBE (Chair) – terminated, 2011.

Honors :
Past
1. Jennifer Ishimoto (PI Dr. Q. Li), graduated 2011; Title: Degradation of pyrene by Mycobacterium species: single versus consortia

Undergraduate students (University of Hawaii) – some of which remained to become graduate students of the Bingham Laboratory:
1. Harlacher, Jenna M. (2013 Fall)
2. Peter Yu (2012 – presently MSc Bingham Laboratory)
3. David Slater (2011 – presently MSc. Bingham Laboratory)
4. Shaun Kiyabu (2011 – presently MSc Bingham Laboratory)
5. William Pryor (2010 – presently Medicine at Medical University of South Carolina)
6. Leilani Manglicmot (2010)
7. Nicholas Fujii (2009 – presently Dentistry at University of Missouri, Kansas City)
8. Steven Gonslaves (2009 – presently Medicine at UH JABSOM)
9. Jessica Leong (2009 – presently Pharmacy)
10. Jeff Milisen (2009 – graduated MSc. from Bingham Laboratory)
11. Parashara Thapa (2009 – presently PhD. Bingham Laboratory)
12. Zan Halford (2009 – presently MSc. Bingham Laboratory)
13. Jaclyn Hara (2008) – practicing pharmacist
14. Jacob Ishibashi (2008 – PhD. Fullerton CA.)

High School science projects at the University of Hawaii:
1. Kristen Morrison (2008) Darien High School, Connecticut – summer internship.

2. Kristel Rodillas and Tyler Kriedler (2011) - Advanced Placement Biology class at Waipahu High School (Hawaiian Malacological Society award at the State Science Fair).

Conference organization:

 Head judge CTAHR for 25th CTAHR and COE Research Symposium, University of Hawaii, Honolulu, April 12-13.
 Scientific Advisory Committee; 23rd American Peptide Society Symposium/6th International Peptides Symposium. Hilton Waikoloa Village Big Island, Hawaii, June 22-27, 2013.
 Judge for Poster competition: 23rd American Peptide Society Symposium/6th International Peptides Symposium. Hilton Waikoloa Village Big Island, Hawaii, June 22-27, 2013.