Last updated on Tuesday, December 2, 2008
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Name : Yangrae Cho
Title : Assistant Professor
Unit : Department of Plant & Environmental Protection Sciences
Address : 3190 Maile Way
Honolulu, HI 96822
Room : St. John 307
Phone : (808)956-5305
Fax : (808)956-2832
E-mail : firstname.lastname@example.org
Research Interests :
- Spore production and pathogenicity. Asexual spore production is of fundamental importance to fugal dispersal and survival. Our research focus is in the molecular bases of fungal asexual spore production and pathogenicity. We have been characterizing the functions of two transcription factor genes using genetics and genomics approaches.
- Population structures of Mycosphaerella at Hawaii. M. fijiensis population structures suggest the presence of multiple strains and movement of these strains within and among the Hawaiian Islands. We have been investigating the extent of pathogen movement; pathogen complexity at the lesion, plant, farm, and island level; emergence of new strains in Hawaii; and the sensitivity of each strain to available fungicides.
- Systematic KO of transcription factor genes: We have developed methods for targeted gene knockout (KO) and knocked out over 100 genes during last two years. For detailed biological studies, we have been using genetics, molecular evolution, functional genomics, and bioinformatics approaches.
- Biotechnology: We are pursuing the production of industrial proteins and secondary metabolites using some of selected fungi for commercialization. We plan to use whole genome sequencing, comparative genomics, and bioinformatics for data handling.
Selected Recent Publications :
- Cho Y, Kim K-H, La Rota M, Scott D, Santopietro G, Callihan M and Lawrence C. 2008. Identification of Novel Virulence Factors Associated with Signal Transduction Pathways in Alternaria brassicicola.Mol. Microbiol. Accepted.
- Sanchez-Puerta MV, Cho Y, Mower JP, Alverson AJ, Gummow J and Palmer JD. 2008. Horizontal transfer of cox1 group I intron among flowering plants: assessing the variation in the coconversion tract.Mol. Biol. Evol. 25(8): 1762-1777.
- Cho Y, Hou S, and Zhong S. 2008. Analysis of expressed sequence tags from the fungal banana pathogen Mycosphaerella fijiensis. The Open Mycology J. The Open mycology J. 2: 61-73.
- Lawrence CB, Mitchell TK, Craven KD, Cho Y, Cramer RA, Kim, KH. 2008. Mini review: At Death’s Door: Alternaria Pathogenicity Mechanisms.Plant Pathology J. 24:101-111.
- Craven KD, Velez H, Cho Y, Hicks R, Lawrence CB, and Mitchell TK. 2008. Anastomosis is required for virulence of the fungal necrotroph, Alternaria brassicicola. Eukaryotic Cell. Eukaryotic Cell 7:675-683.
- Kim K-H, Cho Y, La Rota M, Cramer R and Lawrence CB. 2007 Functional analysis of the Alternaria brassicicola non-ribosomal peptide synthetase gene AbNPS2 reveals a role in conidial cell wall construction.Molecular Plant Pathology 8:23-39.
- Cho Y, Cramer RA, Kim K-H, Michelle T, Figuli B, Pryor BM and Lawrence CB. 2007. The Fus3/Kss1 MAP kinase homolog Amk1 regulates the expression of several hydrolytic enzyme genes in Alternaria brassicicola.Fungal Genetics and Biology 44:543-553.
- Cho Y, Davis J, Kim K-H, Wang J, Sun Q-H, Cramer RA and Lawrence CB. 2006. A High Throughput Targeted Gene Disruption Method for Alternaria brassicicola Functional Genomics Using Linear Minimal Element (LME) Constructs.Mol. Plant-Microbe Interact.19:7-15.