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Name : Qing X Li
Title : Professor
Unit : Department of Molecular Biosciences & BioEngineering
Address : 1955 East-West Rd. #218
Honolulu, HI 96822
Room : Ag Sciences Building 402J
Phone : (808)956-2011
Fax : (808)956-3542
E-mail : email@example.com
Website : http://web.hawaii.edu/lilab/
Specialties : Proteomics;
Agricultural chemistry and biochemistry;
Environmental fate of agrochemicals;
Professional Prep/Appointments :
B.S. Agriculture, 1982, Agricultural University of
and Environmental Chemistry, 1990, University of California at Davis
fellow, 1991-1994, University of California at Berkeley
- Palm peroxidases. We isolate, clone, engineer and express palm peroxidases for biosynthesis of conductive polymers, biosensing and remediation. We study plant glycoprotein heterogeneity, glycoforms and structure and activity relationship.
- Botanical insecticides. We search for novel bioinsecticides and elucidate their mode of action.
- Functional foods. We isolate and characterize natural products for Alzheimer's disease and cancer prevention.
- Food safety, environmental fate and biomonitoring of agrochemicals. We study pesticides and pollutants in foods and the environment. We develop new immunoassays and other analytical methods. We study gas chromatography separation theory, elution model development and computational simulation.
- Microbial stress responses to toxic chemicals and mechanisms of biotransformation. We isolate novel bacteria, Archaea and fungi for bioremediation of pollutants and biosynthesis of high value products. We also study biocontamination of biofuels and blended fuels.
- Proteomics. We study glycoproteomics and phosphoproteomics.
Environmental Biochemistry (MBBE412, 3 credits- lecture
Advanced Laboratory Techniques (MBBE687, 3 credits-
lecture/lab course; Proteomics-focused)
Research Interests :
Our research focuses on agricultural and environmental
chemistry and biochemistry in five areas.
Our research addresses problems relevant to agrochemicals and foods for
human and environment health. Proteomics
is used as a tool for the studies.
1. Palm peroxidases. We isolate, clone, engineer and
express palm peroxidases for biosynthesis of conductive polymers, biosensing
and remediation. We study plant glycoprotein heterogeneity, glycoforms and
structure and activity relationship.
2. Botanical insecticides. We search for novel
bioinsecticides and elucidate their mode of action.
3. Functional foods. We isolate and characterize
natural products for Alzheimer's disease and cancer prevention.
4. Food safety, environmental fate and biomonitoring
of agrochemicals. We study pesticides and pollutants in foods and the
environment. We develop new immunoassays and other analytical methods. We study
gas chromatography separation theory, elution model development and
5. Microbial stress responses to toxic chemicals and
mechanisms of biotransformation. We
isolate novel bacteria, Archaea and fungi for bioremediation of pollutants and
biosynthesis of high value products. We also study biocontamination of biofuels
and blended fuels.
Selected Publications (out of 280)
279. Wu, L.; Duan, X.;
Liu, C.; Zhang, G.; Li, Q.X. 2016. Phenomenon of dual- and single-retention behaviors
of solutes and its validation by computational simulation in linear programmed
temperature gas chromatography. Journal of Separation Science doi
278. Liang, Z.;
Zhang, B.; Su, W.W.; Williams, P.G.; Li, Q.X. 2016. C-Glycosylflavones
alleviate tau phosphorylation and amyloid neurotoxicity through GSK3β
inhibition. ACS Chemical Neuroscience doi: 10.1021/acschemneuro.6b00059
277. Baker, M.R.; Tabb, D.L.; Ching, T.; Zimmerman,
L.J.; Sakharov, I.Y.; Li, Q.X. 2016. Site-specific N-glycosylation
characterization of windmill palm tree peroxidase using novel tools for
analysis of plant glycopeptide mass spectrometry data. Journal of Proteome Research 15(6): 2026-2038.
276. Hennessee, C.T.; Li Q.X. 2016.
Effects of polycyclic aromatic hydrocarbon mixtures on degradation, gene
expression, and metabolite production in four Mycobacterium
species. Applied and Environmental
257. Chu, S.;
Wang, J.; Leong, G.; Woodward, L.A.; Letcher, R.; Li, Q.X. 2015. Perfluoroalkyl sulfonates and
carboxylic acids in liver, muscle and adipose tissues of black-footed albatross
(Phoebastria nigripes) from Midway
Island, North Pacific Ocean. Chemosphere
245. Baker, M.R.; Zhao, H.; Sakharov, I.Y.; Li,
Q.X. 2014. Amino acid sequence of anionic peroxidase from the windmill palm
tree Trachycarpus fortunei. J. Agric. Food Chem. 62(49):11941–11948.
231. Cho, I.K.; Chang, C.L.; Li, Q.X. 2013.
Diet-induced over-expression of flightless-I protein and its relation to flight
dysfunction in Mediterranean fruit fly, Ceratitis
capitata. PLoS ONE 8(12):e81099.
228. Seo, J.-S.; Keum, Y.-S.; Li, Q.X. 2013.
Metabolomic and proteomic insights into carbaryl catabolism by Burkholderia
sp. C3 and degradation of ten N-methylcarbamates. Biodegradation 24:795-811.
226. Baker, M.R.; Li,
Q.X. 2013. Guanidination tryptic peptides without desalting for MALDI MS
analysis. Anal. Chem. 85(18):8873-8880.
218. Wu, L.; Chen M.X.; Chen, Y.; Li, Q.X. 2013. Determination and evaluation
of gas holdup time with the quadratic equation model and comparison with
nonlinear equation models for isothermal gas chromatography. J. Chromatogr.
202. Wang, D.;
Atkinson, S.; Hoover-Miller A.; Shelver, W.; Li, Q.X. 2012. Organic halogenated contaminants in
mother-fetus pairs of harbor seals (Phoca vitulina richardii) from
Alaska, 2000-2002. J. Hazardous Materials 223-224:72-78.
197. Wang, J.; Chen,
W.F.; Li, Q.X. 2012. Rapid identification and classification of Mycobacterium
spp. using whole-cell protein barcodes and selected markers with MALDI TOF MS
in comparison with multigene phylogenetic analysis. Anal. Chim. Acta 716:133-137.
182. Seo, J.-S.; Keum, Y.-S.; Li, Q.X. 2011. Comparative protein and
metabolite profiling revealed metabolic network in response to multiple
environmental contaminants in Mycobacterium aromativorans JS19b1T. J. Agric. Food Chem. 59(7):2876-2882.
175. Wang, D.; Li, Q.X. 2010. Application
of mass spectrometry in the analysis of polybrominated diphenyl ethers. Mass Spectrometry Reviews 29 (5):737-775.
153. Chang, C.L.;
Cho, I.K.; Li, Q.X. 2009. Insecticidal activity of basil oil, trans-anethole, estragole, and linalool
to adult fruit flies of Ceratitis
capitata, Bactrocera dorsalis,
and Bactrocera cucurbitae. J.
Economic Entomology 102(1):
152. Hennessee, C.T.;
Seo, J.-S.; Alvarez, A.M.; Li, Q.X. 2009.
Isolation and characterization of five
new polycyclic aromatic hydrocarbon-degrading species isolated from Hawaiian
soils: Mycobacterium crocinum sp. nov., Mycobacterium
pallens sp. nov., Mycobacterium rutilum sp. nov., Mycobacterium
rufum sp. nov., and Mycobacterium aromaticivorans sp. nov. Int. J. Syst.
Evol. Microbiol. 59(2):378-387.
122. Lee, S.-E.; Seo,
J.S.; Keum, Y.-S.; Lee, K.-J.; Li, Q.X.
2007. Fluoranthene metabolism and associated proteins in Mycobacterium sp.
JS14. Proteomics 7(12):2059-2069.
082. Keum, Y.-S.; Li, Q.X. 2005. Reductive debromination of polybrominated
diphenyl ethers by zero-valent Iron. Environ.
Sci. Technol. 39(7):2280-2286.
081. Hou, S. et al. 2004.
Genome sequence of the deep-sea γ-Proteobacterium Idiomarina Ioihiensis
reveals amino acid fermentation as source of carbon and energy. Proc. Natl. Acad. Sci. USA 101(52):18036-18041.
075. Keum, Y.-S.; Li, Q.X. 2004. Copper dissociation as a mechanism of fungal
laccase denaturation by humic acid. Appl.
Microbiol. Biotech. 64: 588-592.
051. Chiu, Y.-W.; Li, Q.X.; Karu, A.E. 2001. Selective binding of polychlorinated biphenyl
congeners by a monoclonal antibody: analysis by kinetic exclusion fluorescence
immunoassay. Anal. Chem. 73(22):5477-5484.
046. Pellequer, J.L.;
Zhao, B.; Kao, H.-I.; Bell, C.W.; Karu, A.E.; Li, K.; Li, Q.X.; Roberts,
V.A. 2000. Stabilization of bound polycyclic aromatic
hydrocarbons by a p-cation interaction. J. Mol. Biology 302(3):691-699.
045. David, M.D.; Campbell, S.; Li,
Q.X. 2000. Pressurized fluid extraction of polar
herbicides, and polar herbicides using in-situ derivatization. Anal. Chem. 72(15):3665-3670.
042. Thomas, S.D.; Li, Q.X. 2000. Immunoaffinity
chromatography for the analysis of polycyclic aromatic hydrocarbons in corals. Environ. Sci. & Technol. 34(12), 2649-2654.
029. Guo, F.; Li, Q.X.; Alcantara-Licudine,
J.P. 1999. A simple Na4EDTA-assisted
sub/supercritical fluid extraction procedure for quantitative recovery of polar
analytes in soil. Anal. Chem. 71:1309-1315.
027. Li, K.; Chen, R.; Zhao, B.; Liu, M.; Karu
A.E.; Roberts, V.A.; Li, Q.X. 1999. Monoclonal
antibody-based ELISAs for part-per-billion determination of polycyclic aromatic
hydrocarbons: effects of haptens and formats on sensitivity and specificity. Anal.
015. Li, Q.X.;
Casida, J.E. 1994. Structure-activity studies leading to potent chloride
channel blockers: 5e-tert-butyl-2-[4-(substituted-ethynyl)phenyl]-1,3-dithianes. Bioorg.
& Med. Chem. 2(12):1423-1434.
Li, Q.X.; Gee, S.J.; McChesney, M.M.; Hammock, B.D.; Seiber, J.N. 1989.
Comparison of an enzyme-linked immunosorbent assay and a gas
chromatographic procedure for the determination of molinate residues. Anal.