University of Hawai‘i at Manoa
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Last updated on Tuesday, September 1, 2015     Make updates ->

Wei-Wen Winston  Su

Name :

Wei-Wen Winston Su

Title :


Unit :

Department of Molecular Biosciences & BioEngineering

Address :

1955 East-West Rd. #218
                  Honolulu, HI 96822

Room :

Ag Sciences Building 415O

Phone :


Fax :


E-mail :

Specialties :

Biotechnology; Protein engineering; Plant cell Culture; Biochemical engineering; Bioreactor technology; Value adding bioprocessing using microbes and enzymes

Professional Prep/Appointments :

Ph.D., Chemical Engineering, Lehigh University, Bethlehem, PA, June 1991 M.S.E., Chemical Engineering, The Johns Hopkins University, Baltimore, MD, August 1987 B.S., Chemical Engineering National Cheng Kung University, Tainan, Taiwan, June 1985 

Projects :

(Selected Projects)

A novel enabling technology for advancing basic biomedical discoveries and synthesis of protein therapeutics

Expanding the protein co-expression toolbox to advance agricultural biotechnology

Cooperative synthesis of cellulosomes by an engineered yeast consortium to improve lignocellulose bioconversion


Mass and Energy Balances; Bioreactor Design and Analysis  

Research Interests :

  • Bioprocess and biomolecular engineering related to production of recombinant proteins and biochemicals
  • Engineering novel synthetic chimeric proteins
  • Fluorescent proteins
  • Bioenergy and bio-based products from renewable biomass

Selected Publications :


Su, W.W., Zhang, B. 2015. Auto-processing domains for polypeptide expression. US patent 8,945,876, issued on Feb. 3, 2015.

Su, W.W. 2010. Cooperative reporter systems, components, and methods for analyte detection. US patent 7,741,128, issued on June 22, 2010.

Su, W.W. 2007. Sensor constructs and detection methods. US patent 7,247,443, issued on July 24, 2007.

Chang, S., Christopher, D., Vine, B., Su, W.W., Bugos, R. 2006. Plasmodium falciparum merozoite surface protein-1 malaria vaccine produced in transgenic plants.  US Patent 7,037,681 issued May 2, 2006.

Su, W.W. 1994. External-loop perfusion air-lift bioreactor. U.S. Patent 5,342,781.

Selected peer-reviewed publications:

Zhang, B., Rapolu, M., Liang, Z., Han, Z., Williams, P.G., Su, W.W.  2015. A dual-intein autoprocessing domain that directs synchronized protein co-expression in both prokaryotes and eukaryotes. Scientific Reports 5, 8541; DOI:10.1038/srep08541.

Han, Z., Madzak, C., Su, W.W. 2013.  Tunable nano-oleosomes derived from engineered Yarrowia lipolytica.  Biotechnol. Bioeng. 110(3), 702-710.  

Han, Z, Zhang, B., Wang, Y.E., Zuo, Y.Y., Su, W.W. 2012. Self-assembled amyloid-like oligomeric-cohesin scaffoldin for augmented protein display on the Saccharomyces cerevisiae cell surface. Appl. Environ. Microbiol. 78(9), 3249-3255.   

Yang, K., Jenkins, D.M., Su, W.W. 2011. Rapid concentration of bacteria using submicron magnetic anion exchangers for improving PCR-based multiplex pathogen detection. J. Microbiological Methods 86(1), 69-77.   

Zhang, B., Rapolu, M., Huang, L., Su, W.W. 2011. Coordinate expression of multiple proteins in plant cells by exploiting endogenous kex2p-like protease activity. Plant Biotechnology Journal 9, 970-981. 

Yang, K. & Su, W.W. 2011. Facile synthesis of metal-chelating magnetic nanoparticles by exploiting organophosphorous coupling. Anal. Biochem. 408(1), 175-177.  

Su, W.W. 2010. Bioreactors, Perfusion. In: Flickinger, M.C. (ed.) Encyclopedia of Industrial Biotechnology, pp. 978-993, Wiley, New York. (Invited book chapter contribution).

Vardar-Schara, G., Krab, I.M., Yi, G., Su, W.W. 2007. A homogeneous fluorometric assay platform based on novel synthetic proteins. Biochem. Biophys. Res. Commun. 361, 102-108.

Peckham, G. D., Bugos, R.C., Su, W.W. 2006. Purification of GFP fusion proteins from transgenic plant cell cultures. Protein Expr. Purif. 49, 183-189.

Su, W.W., Liu, B., Lu, W.B., Xu, N.S., Du, G.C., Tan, J.L. 2005. Observer-based online compensation of inner filter effect in monitoring fluorescence of GFP-expressing plant cell cultures. Biotechnol. Bioeng. 91(2), 213-226.

Su, W.W. 2005. Fluorescent proteins as tools to aid protein production. Microbial Cell Factories 4, 12.

Languages :

English; Mandarin