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Education/Employment:   

• Associate Professor & Graduate Chair – Dept. of Molecular Bioscience and Bioengineering, University of Hawaii, Honolulu, HI, 2014- present
• Assistant Professor – Dept. of Molecular Bioscience and Bioengineering, University of Hawaii, Honolulu, HI, 2007-2014
• Assist Research Professor – Dept. of Biology, Clarkson University, Potsdam, NY 2003-2007
• Post-doctoral position – Dept. of Pharmacology, Yale School of Medicine, New Haven, CT 2000-2003

• Post-doctoral position – Mass Spectrometry Facility, Dept of Pharmaceutical Chemistry, University of California, San Francisco, CA, 1998-2000
• PhD. in Biochemistry  – Center for Drug Design and Development, Dept of Biochemistry, University of Queensland, Brisbane, Australia, 1993 – 1998
• Thesis Title: Novel Toxins From the Genus Conus – From Taxonomy to toxins Research Area:  Proteomics, drug discovery; solid-phase peptide synthesis and biochemistry of peptide toxins Supervisors: Drs. Paul Alewood and Ross Smith
• B.Sc. (Hons.)  – School of Science, Griffith University, Brisbane, Australia, 1992

• B.Sc.  – School of Science, Griffith University, Brisbane, Australia, 1989 – 1991

Professional Membership:

• The American Peptide Society (2012– present)
• The American Chemical Society (2006 – present)
• Advancing Science, Serving Society (AAAS; 2004 – present)
• The International Society on Toxinology (2003 – present)
• The Malacological Society of Australasia (1992 – present)
• The Federation of Clinical Biochemists (1991– present)

Professional Awards/Recognition:

• Excellence in Instruction College Teaching Award, University of Hawaii, Manoa – 2011
• The Peter V. Garrod Distinguished Graduate Mentoring Award, University of Hawaii, Manoa – 2017

Scientific Advisor/Editor:

• HI State Pesticide Advisory Committee 2017 - Present
• HI State Medical Marijuana Advisory Committee (UH Scientific Representative) 2017 - Present
• Review Editorial Board of Frontiers in Chemical Biology (Frontiers) 2013 – present
• Member of the Editorial Board – Journal of Toxins (Hindawi Publishing Corp) 2012 – present
• Vice President of and Program coordinator to the Hawaiian Malacological Society – 2012 – present
• President of and Scientific Advisor to the Hawaiian Malacological Society – 2011 – 2012
• Board Director and Scientific Advisor to the Hawaiian Malacological Society – 2009 – 2010

Projects :

Pesticide development

Research: Terrestrial and aquatic mollusks cause serious crop damage, as well as present serious health concerns to both agricultural workers and produce consumers alike. Present molluscicides are ineffective, non-selective, non-biodegradable, residual forming AND costly (reflected in the rising price of copper salts, which are an active constituent in snail baits). Combined, these represent serious concerns in food safety and security, pest management, environmental impact and tropical human health.

Hawai’i has not escaped these growing concerns, which have seen mass infestations, crop losses (e.g. Taro, water cress, herbs etc.) and has sadly been directly implicated in a number of human deaths on the Big Island (via Angiostrongylus cantonensis / Rat Lung worm – a snail vector-borne parasitic disease). What we are facing here in Hawai’i is not an isolated issue, but is clearly becoming a concern for health care professionals and agriculturalists in both developing and developed countries.

Noting: Intestinal helminthes (some which are snail vector-borne) are the most common of all human parasites, and schistosomiasis (solely snail vector-borne) is second only to malaria in the public health impact of all vector-borne tropical diseases. Thus the control of snail populations worldwide is directly interrelated to food production/supply, food safety and to human health.

The primary goal of my research is to interface agriculture research and medicine. We achieve this via researching the use of phyla-selective peptide toxins to control pests – specifically snails, as well as fueling the discovery of new human biopharmaceuticals using novel biosustainable approaches in aquaculture/animal husbandry to ensure a present and future supply of biologics.

Using venom extracts from the marine snails from the genus Conus, we characterize novel toxin candidates from captive (dietary manipulated) animals, then integrating both synthetic peptide chemistry and bioengineering strategies to produce novel toxin candidate variants for field-testing (and medical research). These efforts include bioengineering of novel fluorescent receptor probes, the establishment of phyla-selective/ receptor isoform-selective high throughput assays for discovery, designing peptide candidate templates for specific applications (i.e. receptor targets) or biological characteristics (i.e. biodegradability).

The impact of peptide chemistry in medicine has become clearly evident, yet for agricultural applications or use veterinary science there is a significant lag. This is one area that my research laboratory is moving towards changing.

Value-Added Products from Agriculture - Brewery Sciences

Courses:

MBBE/BIOL 402 Biochemistry (Spring) (4 Cr)
MBBE 691 Fermentation Biochemistry (Spring) (3 Cr)
MBBE 610 Seminar  - Professional Development (Spring/Fall) (1 Cr)
MBBE 691 Special Topics - Building a better graduate community (Spring/Fall)(1-3 Cr)

Previously Taught
BIOL 402L Biochemistry Laboratory (Spring) (2 Cr)

Professional Interests :

Publications :

Mau, A. Bingham, J., Soller, F., and Jha, R. (2018) Maturation, spawning, and larval development in captive yellowfoot limpets (Cellana sandwicensis) Invertebrate Reproduction and Development 62(4):239-247.

Oeser SG, Bingham JP, Collier AC. (2018) Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent.

Pharmaceutics. 2018 Jan 7;10(1). pii: E6. doi: 10.3390/pharmaceutics10010006.

Zhang R-Y., Thapa P., M.J. Espiritu M.J., Menon V., Bingham JP. (2017) From Nature to Creation: Going around in Circles, the Art of Peptide Cyclization. Bioorganic & Medicinal Chemistry, 26 (6): 1135-1150.

Mau, A., Fox, K., and Bingham, J. (2017) The Reported Occurrence of Hermaphroditism in the Yellowfoot Limpet (Cellana sandwicensis Pease, 1981) Annals of Aquaculture and Research 4(4): 1045.

Thapa P., Cabalteja C.C., Philips E.E. 3rd, Espiritu M.J., Peigneur S., Mille B.G., Tytgat J., Cummins T.R., Bingham J.P. (2016) t-boc synthesis of huwentoxin-i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy. Biopolymers. 106(5):737-45