Last updated on Monday, February 20, 2023
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 Name : Andre P. Seale
Title : Associate Research Professor
Unit : Department of Human Nutrition, Food & Animal Sciences
Address : 1955 East West Rd.
Honolulu, HI 96822
Room : Ag Sciences Building 314G
Phone : (808) 956-8961
Fax : (808) 956-4024
E-mail : seale@hawaii.edu
Specialties : Comparative endocrinology, fish physiology, cell and molecular biology, signal transduction, aquaculture.
Professional Prep/Appointments :
Ph.D., University of Hawaiʻi (Zoology)
B.S., University of Miami (Marine Biology
Projects :
Resolving impediments to captive longevity and fecundity in Seriolids, Americaʻs most successful offshore marine fish species (NOAA).
Identifying the physiological responses to extreme environmental changes in native Hawaiian sea cucumbers (UH Sea Grant)
Establishing a Hawaiʻi-Pacific aquaculture consortium: a revitalization and expansion of the aquaculture development program (NOAA).
Establishing an aquaculture program at the University of Hawaii that leverages and integrates Land Grant and Sea Grant research, extension and education resources (NOAA).
Collaborative Research: Identifying osmosensitive molecular targets using a unique vertebrate model (NSF).
Integrating osmosensitivity and autocrine signaling in a model for osmoregulation (NIH).
USDA/ HATCH: Physiological effects of environmental stressors in a key finfish for aquaculture (USDA/ HATCH).
Courses:
ANSC472
ANSC450/ OCN450
ANSC499
ANSC491
ANSC699/ MBBE699/ CMB699
ANSC700/ MBBE700/ CMB700
Research Interests :
With broader implications to aquaculture and biomedical research, my main interests are in: 1) osmoreception: the signal transduction of environmental salinity changes into physiological responses at the cellular and organismic levels in fish; regulation of prolactin cells by external and neuroendocrine factors and the role of second messenger systems; 2) osmoregulation: salt and water balance and its interplay with growth, metabolism and stress in fish; and 3) environmental adaptation and growth in fish: endocrine and specialized cellular responses to changing environmental conditions.
Selected Publications :
Seale, A. P., Breves, J. P. (2022). Endocrine and osmoregulatory responses to tidally-changing salinities in fishes. Gen. Comp. Endocrinol. 326, 114071.
Woo, D. W., Malintha, G. H. T., Celino-Brady, F. T., Yamaguchi, Y., Breves, J. P., Seale, A. P. (2022). Tilapia prolactin cells are thermosensitive osmoreceptors. Am. J. Physiol. https://doi.org/10.1152/ajpregu.00027.2022.
Seale, L. A., Gilman, C. L., Zavacki, A. M., Larsen, P. R., Inokuchi, M., Breves, J. P., Seale, A. P. (2021) Regulation of thyroid hormones and branchial iodothyronine deiodinases during freshwater acclimation in tilapia. Mol. Cell. Endocrinol. 538: 111450. doi: 10.1016/j.mce.2021.111450
Breves, J. P., Nelson, N. N., Koltenyuk, V., Petro-Sakuma, C., Celino-Brady, F. T., Seale, A. P. (2021) Enhanced expression of ncc1 and clc2c in the kidney and urinary bladder accompanies freshwater acclimation in Mozambique tilapia. Comp. Biochem. Physiol. 260: 111021; doi: 10.1016/j.cbpa.2021.111021
Inokuchi, M., Moorman, B., Yamaguchi, Y., Seale, A. P. (2021). Age-dependent decline in salinity tolerance in a euryhaline fish. Front. Aging. 2: 15.
Celino-Brady, F., Lerner, D. T., Seale, A. P. (2021). Experimental Approaches for Characterizing the Endocrine Disrupting Effects of Environmental Chemicals in Fish. Front. Endocrinol. 11:1170.
Seale, A. P., Malintha, T., Celino-Brady, F. T., Head, T., Belcaid, M, Yamaguchi, Y., Lerner, D. T., Baltzegar, D. A., Borski, R. J., Stoytcheva, Z. R. and Breves, J. P. (2020). Transcriptional regulation of prolactin in a euryhaline teleost: characterization of gene promoters through in silico and transcriptome analyses. J. Neuroendocrinol. 32: e12905.
Petro-Sakuma, C. K., Celino-Brady, F., Breves, J. P., Seale, A. P. (2020). Growth hormone regulates intestinal gene expression of nutrient transporters in tilapia, Oreochromis mossambicus. Gen. Comp. Endocrinol. 292: 113464.
Seale, A. P., Pavlosky, K. K., Celino-Brady, F., Lerner, D. T. (2020). Sex, salinity and sampling period dependent patterns of growth hormone mRNA expression in Mozambique tilapia. Aquaculture. 519: 734766.
Celino-Brady, F., Petro-Sakuma, C. K., Breves, J. P., Lerner, D. T., Seale, A. P. (2019). Early-life exposure to 17β-estradiol and 4-nonylphenol impacts the growth hormone/insulin-like growth-factor system and estrogen receptors in Mozambique tilapia, Oreochromis mossambicus. J. Aqua. Tox. 217: 105336.
Seale, A. P., Pavlosky, K. K., Celino-Brady, F., Yamaguchi, Y., Breves, J. P., Lerner, D. T. (2019). Systemic versus tissue-level modulation of prolactin signaling in a euryhaline teleost subjected to tidally changing slainities. J. Comp. Physiol.189, 581-594.
Pavlosky, K. K., Yamaguchi, Y., Lerner, D. T., Seale, A. P. (2019). The effects of transfer from steady-state to tidally-changing salinities on plasma and branchial osmoregulatory parameters in adult Mozambique tilapia. Comp. Biochem. Physiol. 227: 134-145.
Douros, J. D., Baltzegar, D. A., Reading, B. J., Seale, A. P., Lerner, D. T., Grau, E. G., Borski, R. J. (2018). Leptin stimulates cellular glycolysis through a STAT3 dependent mechanism in tilapia. Front. Endocrinol. 9, 465.
Yamaguchi, Y., Breves, J. P., Haws, M. C., Lerner, D. T., Grau, E. G., Seale, A. P. (2018). Acute salinity tolerance and the control of prolactin 177 and prolactin 188 release and gene expression by extracellular osmolality in the Nile tilapia: a comparative study. Gen. Comp. Endocrinol. 257, 168-176.
Breves, J. P., Keith, P. L. K., Hunt, B. L., Pavlosky, K. K., Inokuchi, M., Yamaguchi, Y., Lerner, D. T., Seale, A. P., Grau, E. G. (2017). clc-2c is regulated by salinity, prolactin and extracellular osmolality in tilapia gill. J. Mol. Endocrinol. 59(4):391-402
Douros, J. D., Baltzegar, D. A., Mankiewicz, J. L.; Taylor, J. D., Yamaguchi, Y., Lerner, D. T., Seale, A. P., Grau, E. G., Breves, J. P., Borski, R. J. (2017). Control of leptin by metabolic state and its regulatory interactions with pituitary growth hormone and hepatic growth hormone receptors and insulin like growth factors in the tilapia (Oreochromis mossambicus). Gen. Comp. Endocrinol. 240, 227-237.
Breves, J., Inokuchi, M., Yamaguchi, Y., Seale, A. P., Watanabe, Lerner, D. T., S., Kaneko, T., Grau, E. G. (2016). Hormonal regulation of aquaporin 3 in tilapia gill: opposing actions of prolactin and cortisol. J. Endocrinol. 230, 325-337.
Moorman, B. P., Yamaguchi, Y., Lerner, D. T., Grau, E. G., Seale, A. P. (2016) Rearing Mozambique tilapia in tidally-changing salinities: effects on growth and the growth hormone/ insulin-like growth factor I axis. Comp. Physiol. Biochem.198, 8-14.
Yamaguchi, Y.,Moriyama S., Lerner, D. T., Grau, E. G., Seale, A. P. (2016). Autocrine regulation of prolactin release from tilapia prolactin cells: modulation of hormonal responses by extracellular osmolality. Endocrinology. 157, 3505-16
Yamaguchi, Y., Takagi, W., Kuraku, S., Moriyama, S., Bell, J. D., Seale, A. P., Lerner, D. T., Grau, E. G., Hyodo, S. (2015). Discovery of conventional prolactin from the holocephalan elephant fish, Callorhinchus milii. Gen. Comp. Endocrinol. 224, 216-227.
Nakamura, M., Nozu, R., Ijiri, S., Kobayashi, T., Yamaguchi, Y., Seale, A. P., Lerner, D.T., Grau, E. G. (2015). Sexual characteristics of high-temperature sterilized male Mozambique tilapia, Oreochromis mossambicus. Zool. Lett. 1-21
Inokuchi, M., Breves, J., Moriyama, S., Watanabe, S., Kaneko, T., Lerner, D. T., Grau, E. G., Seale, A. P. (2015). Prolactin 177, prolactin 188 and extracellular osmolality independently regulate the expression of ion transport effectors in the gills of Mozambique tilapia. Am. J. Physiol. 309(10): R1251-1263.
Furukawa, F., Watanabe, S., Seale, A. P., Breves, J. P., Lerner, D. T., Grau, E. G., Kaneko, T. (2015). In vivo and in vitro studies reveal that branchial expression of ROMKa in seawater-acclimated Mozambique tilapia directly responds to high-K+ stress. Comp. Biochem. Physiol. 187, 111-118.
Moorman, B. P., Lerner, D. T., Grau, E. G., Seale, A. P. (2015). The effects of acute salinity challenges on Osmoregulation in Mozambique tilapia reared in a tidally changing salinity. J. Exp. Biol. 218, 731-9.
Zikos, A., Seale, A. P., Lerner, D. T., Grau, E. G., Korsmeyer, K. E. (2014). Effects of salinity on metabolic rate and branchial expression of genes involved in metabolism and mitochondrial biogenesis in Mozambique Tilapia (Oreochromis mossambicus). Comp. Biochem. Physiol. 178, 121-31.
Seale, A.P., Stagg, J. J., Yamaguchi, Y., Breves, J. P., Soma, S., Watanabe, S., Kaneko, T., Cnaani, A., Harpaz, S., Lerner, D. T., Grau, E.G. (2014). Effects of salinity and prolactin on the transcription of ion transporters, ion pumps and prolactin receptors in Mozambique tilapia intestine. Gen. Comp. Endocrinol. 206, 146-54.
Seale, L. A., Gilman, C. L., Moorman, B. P., Berry, M. J., Grau, E.G., Seale, A.P. (2014). Effects of acclimation salinity on the expression of selenoproteins in the tilapia, Oreochromis mossambicus. J. Tr. El. Med. Biol. 28(3), 284-92.
Douros, J. D., Baltzegar, D. A., Breves, J. P., Lerner, D. T., Seale, A. P., Grau, E. G., Borski, R. J. (2014) Prolactin is a major inhibitor of hepatic Leptin A synthesis and secretion: studies utilizing a homologous Leptin A ELISA in the tilapia. Gen. Comp. Endocrinol. 207, 86-93.
Breves, J. P., Tipsmark, C. K., Stough, B. A., Seale, A. P., Flack, B. R., Moorman, B. P., Lerner, D. T., Gau, E. G. (2014) Nutritional status and growth hormone regulate insulin-like growth factor binding protein (IGFBP) transcripts in Mozambique tilapia. Gen. Comp. Endocrinol. 207, 66-73.
Moorman, B. P., Inokuchi, M., Yamaguchi, Y., Lerner, D. T., Grau, E. G., Seale, A. P. (2014). The osmoregulatory effects of rearing Mozambique tilapia in a tidally changing salinity. Gen. Comp. Endocrinol. 207, 94-102.
Breves J. P., Seale, A.P., Moorman, B. P., Lerner, D. T., Moriyama, S., Hopkins, K. D., Grau, E.G. (2014). Pituitary control of branchial NCC, NKCC and Na+, K+-ATPase alpha-subunit gene expression in Nile tilapia, Oreochromis niloticus. J. Comp. Physiol. 184, 513-523.
Seale, A.P., Yamaguchi, Y., Johnstone III, W.M., Borski, R.J., Lerner, D.T. Grau, E.G. (2013). Endocrine regulation of prolactin cell function and modulation of osmoreception in the Mozambique tilapia. Gen. Comp. Endocrinol. 192, 191-203.
Seale, A.P., Watanabe, S., Breves, J. P, Lerner D.T., Grau, E.G. (2012). Differential regulation of TRPV4 by acclimation salinity and extracellular osmolality in euryhaline tilapia. Gen Comp. Endocrinol. 178, 123-130.
Seale, A.P., and Watanabe, S., Grau, E. G. (2012). Osmoreception: perspectives on signal transduction and environmental modulation. Gen. Comp. Endocrinol. 176, 354-360.
Seale, A.P., Moorman B. P., Stagg, J. J., Breves, J. P., Lerner, D. T., Grau, E.G. (2012). Prolactin 177, prolactin 188 and prolactin receptor 2 in the pituitary of the euryhaline tilapia, Oreochromis mossambicus, are differentially osmosensitive. J. Endocrinol . 213, 89-98.
Watanabe, S., Seale, A.P., Grau, E.G, Kaneko, T. (2012). TRPV4 stretch-activated cation channel mediates hyposmolality-induced prolactin release from prolactin-producing cells of Mozambique tilapia, Oreochromis mossambicus. Am. J. Physiol. 302, R1004-1011.
Tipsmark, C. K., Breves, J. P., Seale, A. P., Lerner, D. T., Hirano, T., Grau, E. G. (2011).Switching of Na+, K+-ATPase isoform gene expression by salinity and prolactin in the gill of a euryhaline cichlid. J. Endocrinol. 209, 237-44.
Seale, A.P., Mita, M., Hirano, T., and Grau, E. G. (2011). Involvement of the cAMP messenger system and extracellular Ca2+ during hyposmotically-induced prolactin release in the Mozambique tilapia. Gen. Comp. Endocrinol. 170, 401-407.
Seale, A. P., Hirano, T., and Grau, E. G. (2006). Osmoreception: a fish model for a fundamental sensory modality. In "Fish Endocrinology" (G. Zaccone and M. Reinecke, Eds.)., pp. 419-440 Oxford & IBH Publishing Company.
Seale, A. P., Fiess, J. C., Hirano, T., Cooke, I. M., and Grau, E. G. (2006). Disparate release of prolactin and growth hormone from the tilapia pituitary in response to osmotic stimulation. Gen. Comp. Endocrinol. 145, 222-31.
Shepherd, B. S., Weber, G. M., Vijayan, M. M., Seale, A. P., Riley, L. G., Richman, N. H., Hirano, T., and Grau, E. G. (2005). Control of growth in tilapia: developments and prospects. In "Tilapias: Culture, Nutrition and Feeding" (C. D. Webster and C. E. Lim, Eds.). Haworth Press.
Kajimura, S., Seale, A.P., Hirano, T., and Grau, E. G. (2005). Physiological Concentrations of Ouabain Rapidly Inhibit Prolactin Release from the Tilapia Pituitary. Gen. Comp. Endocrinol. 143, 240-50.
Hyde, G. N., Seale, A. P., Grau, E. G., and Borski, R. J. (2004). Cortisol rapidly suppresses intracellular calcium and voltage-gated calcium channel activity in prolactin cells of the tilapia (Oreochromis mossambicus). Am J. Physiol. Endocrinol. Metab. 286, E626-33.
Seale, A. P., Cooke, I., Hirano, T., and Grau, G. (2004). Evidence that IP(3) and Ryanodine-sensitive Intra-cellular Ca Stores are not Involved in Acute Hyposmotically-Induced Prolactin Release in Tilapia. Cell. Physiol. Biochem. 14, 155-66.
Seale, A. P., Richman, N. H., 3rd, Hirano, T., Cooke, I., and Grau, E. G. (2003). Cell volume increase and extracellular Ca2+ are needed for hyposmotically induced prolactin release in tilapia. Am. J. Physiol. Cell Physiol. 284, C1280-9.
Seale, A. P., Richman, N. H., 3rd, Hirano, T., Cooke, I., and Grau, E. G. (2003). Evidence that signal transduction for osmoreception is mediated by stretch-activated ion channels in tilapia. Am. J. Physiol. Cell Physiol. 284, C1290-6.
Seale, A. P., Itoh, T., Moriyama, S., Takahashi, A., Kawauchi, H., Sakamoto, T., Fujimoto, M., Riley, L. G., Hirano, T., and Grau, E. G. (2002). Isolation and characterization of a homologue of mammalian prolactin-releasing peptide from the tilapia brain and its effect on prolactin release from the tilapia pituitary. Gen. Comp. Endocrinol. 125, 328-39.
Seale, A. P., Riley, L. G., Leedom, T. A., Kajimura, S., Dores, R. M., Hirano, T., and Grau, E. G. (2002). Effects of environmental osmolality on release of prolactin, growth hormone and ACTH from the tilapia pituitary. Gen. Comp. Endocrinol. 128, 91-101.
Languages :
English, Portuguese
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